BPC157 CAS 137525-51-0

Product Description:

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H2O2 stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

Who Needs This Peptide?

Based on test results on animal subjects, this peptide will be best for human beings who’ve experienced digestive difficulties of a chronic or sporadic nature. In addition, it may help people to recover from muscle injuries and to heal from wounds.
Now, let’s talk about a couple of specific health conditions which may be improved via usage of this peptide.
This peptide may have the power to treat Ulcerative Colitis, which is an ailment in the colon which triggers ulcers and/or open sores. In addition, it may have the power to help people who suffer from Crohn’s Disease, which is a chronic disorder which triggers inflammation in the digestive tract.
This peptide is to be considered an experimental treatment. Animal test subjects experienced faster wound healing when they were injected with this peptide. The peptide also seems to promote longer life of cells that are under stress, such as cells at wound sites. Traumatized cells respond to treatment with the peptide by healing and regenerating at a faster than average rate.
In particular, bodybuilders may find that this peptide offers great promise in terms of its ability to speed heal wounds, reduce inflammation and repair damaged muscle tissue. Those who have used this research peptide or “synthed” versions notice tangible improvements very quickly.

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